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Description

Instead of efficient aerobic energy production, the cells are forced into an inefficient anaerobic state, producing excess lactate

Urry, Timothy J

Pharmacognosy Res 9(2):182187

Plant sterol esters from -linolenic acid activate SIRT1, downregulating NLRP3 and ASC expression, reducing colocalization with cleaved caspase-1, and lowering GSDMD cleavage, thereby inhibiting hepatocyte pyroptosis and slowing MASH progression in mice